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This in turn reduces melanin production

While this has some inherent logic, it has not been fully explored whether it is valid to assume a linearity of the relationship between gene and serum UA in which genetic polymorphisms differentiating normal and high UA associated with, say, risk of gout are the same as those differentiating normal and low UA associated with risk of PD

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In addition to the well-known changes in cardiovascular hemodynamics in anemia, changes in intrinsic properties of RBCs may contribute to the systemic effects observed in anemia